XXIII Olympic Winter Games PyeongChang 2018 - Anti-Doping Information

I - Anabolic agents:

Two new substances have been added to the category of selective androgen receptor modulators (SARMs): LGD-4033 (Ligandrol) and RAD-140 (Testolone).

 S3. b2-agonists:

Salbutamol prescribing protocols have been revised to clarify that divided doses of salbutamol should not exceed 800 micrograms in any 12 hour period.

Tulobuterol (not marketed in France) has been added as an example of a banned β2-agonist.

 S4. Hormonal and metabolic modulators:

SR9009, a Rev-Erb-? Agonist, was added as an example of AMP-activated protein kinase activator (AMPK) (biological effects similar to AICAR).

 S5. Diuretics and masking agents:

Given the state of scientific knowledge acquired since 2012, the potential effects of glycerol on the parameters of the athlete's biological passport (ABP), are now considered minor. As a result, glycerol was removed from the Prohibited List.

S8. Cannabinoids :

The Cannabimimetics subgroup (eg “Spice, JWH-018, JWH-073, HU210”) has had its name changed to “Synthetic Cannabinoids” (eg? 9-tetrahydrocannabinol (THC)) and other cannabimimetics) .

Synthetic cannabinoids are one of the major classes of new psychoactive substances that constantly include new drugs. The substances mentioned above continue to be banned. The generic term "other cannabimimetics" replaced these examples.

Cannabidiol is no longer prohibited. Synthetic cannabidiol does not contain any cannabimimetic substances; however, cannabidiol extracted from cannabis plants may also contain varying concentrations of THC, which remains a prohibited substance.

S9. Glucocorticoids:

Examples of commonly used glucocorticoids have been added for clarity.

Including without limitation:

- Betamethasone;
- Budesonide;
- Cortisone;
- Deflazacor t;
- Dexamethasone;
- Fluticasone;
- Hydrocortisone;
- Methylprednisolone;
- Prednisolone;
- Prednisone;
- Triamcinolone.

The anti-doping rules of the International Olympic Committee (IOC) will be in effect during the Games, which will begin on February 1, 2018 (at the opening of the Athletes' Village) and end on February 25, 2018 (at the end of the Closing Ceremonies). During this period, athletes may undergo IOC doping controls. As always, athletes could be notified anytime, anywhere in the world, without notice.

These rules are available on the website of the World Anti-Doping Agency (www.wada-ama.org) under the title “International Olympic Committee Anti-Doping Rules Applicable to the Olympic Winter Games PyeongChang 2018”.

The 2018 Prohibited List of the World Anti-Doping Agency (WADA) was made public on September 29, 2017 and entered into force on January 1, 2018.

It is available on the website of Monegasque Anti-Doping Committee.

Compared to the previous List, it includes some new features:

II - Peptide hormones, growth factors, related substances:

- Section 2.2.1. Chorionic Gonadotropin (and LH) releasing factors.

Deslorelin, goserelin, nafarelin and triptorelin have been added as new examples of such substances.

- Section 2.2.3. GH, its fragments and its releasing factors.

Fragments of growth hormone have been included: e.g. AOD-9604 and 176-191

GHRH analogues have been added: CJC-1293. Another example of a growth hormone secretagogue has been added, tabimorelin.

Other examples of GH releasing peptides (GHRPs): GHRP-1, -3, -4, and -5.

- Section 2.3. Growth factors.

Thymosin-ß4 and its derivatives, e.g. TB-500, were added as examples of prohibited growth factors.

Cobalt: it is recalled that vitamin B12, which contains cobalt, is not prohibited.

M2. Chemical and physical manipulations:

The authorized volume and duration of intravenous injections have been changed from infusions / injections of less than 50 mL per 6 hour period, to infusions / injections of less than 100 mL in total, per 12 hour period. This is to allow greater flexibility for the safe administration of non-prohibited therapeutic substances (eg, as part of iron supplementation).

M3. Genetic doping:

In order to take into account the most current gene manipulation technologies, some definitions have been adjusted. More clearly, the uses are now prohibited:

1.-polymers of nucleic acids or nucleic acid analogues;

2.- genomic editing agents designed to modify genomic sequences and / or the transcriptional or epigenetic regulation of gene expression;

3.- normal or genetically modified cells.

III - Alcohol

Alcohol has been removed from the Prohibited List. The purpose of this change is not to compromise the integrity or safety of sports where alcohol is a concern, but rather to support the implementation of alternative means of imposing bans on alcohol consumption in these sports.

The International Federations (IFs) affected by this change have been informed sufficiently in advance to change their rules and to put in place protocols to test alcohol consumption and adequately sanction athletes who do not follow the rules. of their sport. Process control will give FIs more individual flexibility in applying rules or thresholds.

National anti-doping organizations will no longer be obliged to carry out controls, but will be able to help IFs and national federations if necessary.

 Monitoring program:

The following substances have been added:

- 2-ethylsulfanyl-1H-benzimidazole (bémitil): monitoring In and Out of competition

- Hydrocodone: monitoring In competition

- Mitragynine and telmisartan were withdrawn from the monitoring program because the expected information was obtained.

Each athlete can check the site's database to see if the medicine they are taking contains an illegal substance or uses a prohibited method of administration. This database only targets drugs and substances authorized for sale in France and Monaco. For other drugs, refer to the databases of the countries concerned.

All samples taken by the CMA, the International Federations (IFs) and the IOC as of 1st January 2018 will be tested for substances and methods that appear in this 2018 Prohibited List.

According to the IOC Anti-Doping Rules, samples taken during the 12-hour period before the start of the competition and until its end will be analyzed taking into account all the substances and methods that appear in the 2018 Prohibited List of the competition. 'AMA. A competition refers to a race, a match or a game.

Samples taken outside of an athlete's competition period will be analyzed for substances and methods prohibited out of competition only.

During the Games, in accordance with the rights and responsibilities of athletes under the Anti-Doping Program, the Athletes of Monaco are:

• encouraged to be accompanied during doping control so that this person acts as a representative and helps with translation and interpretation, as required;
• invited to report their concerns regarding the doping control process in a Supplementary Report (if applicable) or in the Comments section of the Doping Control Form;
• are re-informed that once they have been advised that they are to undergo doping control, they must proceed immediately to the doping control station, unless they request a delay for a valid reason and that it be approved by the anti-doping team responsible for the 2018 Games in PyeongChang.

Valid reasons for requiring a delay before going to a doping control station include:

• Take part in a recovery period;
• Obtain medical treatment;
• Fulfill a media engagement;
• Participate in a training session;
• Attend a medal ceremony.

If an athlete obtains a delay to report to a doping control station or to leave a doping control station, he must be accompanied by an athlete notification and accompaniment officer also called an “escort” or “chaperone”. .

The Committee's website is available for further anti-doping information, including Sample collection procedures and the rights and responsibilities of athletes.

As of January 1, 2018, athletes who need to take prescription or over-the-counter medications should check the status of all their medications to determine if they are in the WADA's 2018 Prohibited List.

In Monaco, athletes can check their medication by:

• using the database of the CMA site;
• sending an email to  alessio@www.onad-monaco.mc;
• calling the CMA on +377 97 77 56 49;
• contacting their team doctor or the Monegasque Olympic Committee doctor assigned to their sport.

During the Games, athletes should consult a COC team doctor regarding their medication.

According to the IOC anti-doping rules, Monegasque athletes who take prohibited substances for justified medical reasons must hold before the Games a therapeutic use authorization (TUE), which can be found in ADAMS.

The IOC Medical and Scientific Commission advises athletes to “treat TUE requests seriously and seek expert help in all cases. Using a prohibited substance or method that is on the 2018 Prohibited List before or without obtaining a TUE constitutes an anti-doping rule violation (ADRV) ”(International Olympic Committee, 2017).

Effective today, to meet IOC TUE requirements, the CMA recommends that Athletes who hold a CMA or their IF TUE verify the following:

• TUE expiration date- to ensure that it is valid during the Games;
• Medicine and dosage of TUE- to ensure that they take into account the current treatment plan;
• TUE Mandated Authority- Athletes who would hold a TUE from the CMA should check their IF's TUE requirements for the Games.

Monegasque athletes who need a TUE must:

• Before the Games- communicate with their FI to find out about TUE requirements;
• During the Games- submit a request to the IOC Medical and Scientific Commission. Team doctors will facilitate this process.

In all cases, athletes must keep their team doctor and COC Chief Medical Officer informed of the status of their TUE application.

Athletes can obtain additional information on TUEs by:

• consulting the permanent secretariat of the CMA on +377 97 77 56 49;
• sending an email to andrea.alessio@www.onad-monaco.mc;

The IOC Medical and Scientific Commission declares that the Games are “syringe-free” for all participating athletes. Only qualified healthcare professionals (doctors or nurses) may use syringes for justified clinical treatment, which must be declared on the designated IOC form. Exceptionally, syringes can also be used for self-injections by athletes whose clinical conditions require self-injections and who hold a corresponding valid TUE (eg, insulin-dependent diabetics) ”(International Olympic Committee, 2017). 

The IOC Medical and Scientific Commission reminds athletes that “the use of nutritional supplements is not recommended, as your samples could reveal the presence of prohibited substances. Supplements should only be used for medical reasons and always under the supervision of a medical professional (such as the team doctor or sports nutritionist) to minimize the risk of your samples revealing the presence of prohibited substances ”( International Olympic Committee, 2017).

The CMA reiterates that there is no way to guarantee that a supplement does not contain prohibited substances, even supplements for which no prohibited substance is listed on their label. As athletes are responsible for everything in their sample, they are called upon to exercise the utmost vigilance.

In November 2015, the IOC Medical and Scientific Commission set up a group of experts to analyze the available scientific and clinical evidence on gender reassignment and hyperandrogenism. As was the case during the Rio 2016 Olympics, the IOC will not be imposing any further rules on hyperandrogenic female athletes for the 2018 Olympic Winter Games in PyeongChang.